Abstract

Purpose:To prepare magnetic solid lipid nanoparticles (MSLN) containing Ibuprofen (IB) by an emulsification dispersion-ultrasonic method. Methods: Ibuprofen (IB) was chosen as a model drug loaded on MSLN. Magnetite can be synthesized by co-precipitation from a ferrous and ferric aqueous solution by addition of a base, and the magnetite nanoparticles should be coated with oleic acid during precipitation process. Magnetic solid lipid nanoparticles (MSLN) containing Ibuprofen (IB) were prepared by an emulsification dispersion-ultrasonic method. We attempted to control the properties of the magnetic composite lipid particles and the degree of magnetite-loading by altering the SLN formulation. The IB-MSLN were characterized by transmission electron microscopy (TEM), x-ray powder diffraction and a superconducting quantum interference device (SQUID) magnetometer, a laser particle sizer, and a Zeta potential analyzer. Results:The drug encapsulation efficiency (EE%) showed that the about 80% of the drug is efficiently entrapped by MSLN. The IB-MSLNs , embedded with the magnetite nanoparticles (~7 nm), were spherical and uniform as shown by TEM, SQUID measurements indicated that IB-MSLN exhibited superparamagnetic behavior with a blocking temperature (TB) of 86 K. The coercivity of IB-MSLN at 5K was found to be 215Oe. Conclusions: The prepared MSLN particles will be useful for applications involving drug targeting and controlled drug release.


Keywords:  Magnetic solid lipid nanoparticles   Ibuprofen   Preparation   Characterization   Drug targeting