Abstract

As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. It is a great challenge for pharmaceutical scientists to convert those molecules into orally administered formulations with sufficient bioavailability. Among the approaches to improve the oral bioavailability of these molecules, the use of self-emulsified drug delivery systems (SEDDS) has been shown to be reasonably successful in improving the oral bioavailability of poorly water-soluble and lipophilic drugs. The present review examines the recent advances in Solid SEDDS (S-SEDDS) with regard to the selection of lipid systems for current formulations, solidification techniques and the development of solid SE (self-emulsifying) dosage forms and their related problems and possible future research directions.



Keywords:  Lipid-based formulation   Self-emulsifying drug delivery system   Lipid formulation classification system   Excipient   Surfactant   Self-dispersion