Xanthan and locust bean gum (from Ceratonia siliqua) matrix tablets for oral controlled delivery of propranolol hydrochloride
M. P. Venkataraju1*, D. V. Gowda1, K. S. Rajesh2, H. G. Shivakumar1
1Department of Pharmaceutics, J. S. S. College of Pharmacy, S. S. Nagar, Mysore, India2Department of Pharmaceutics, Parul Institute of Pharmacy, Baroda, India
Abstract Purpose: To develop a controlled delivery system for propranolol hydrochloride (PPHCL) using the synergistic activity of locust bean gum (LBG) and xanthan gum (X). Methods: Granules of PPHCL were prepared by using different drug: gum ratios of X, LBG alone and a mixture of XLBG (X and LBG in 1:1 ratios). To increase the flowability and compressibility of the granules, and to prevent its adhesion to the punch and die, magnesium stearate (Mg. st) and talc were added to the granules in a 1:2 ratio before punching. The tablets were analysed to determine their hardness, friability, and composition% and an in vitro release study was carried out. Results: The release of PPHCL from a gelatinous swollen mass controls the diffusion of drug molecules through the polymeric material into aqueous medium. The XLBG matrices exhibited precise controlled release than the X and LBG matrices because of burst effect and fast release in case of X and LBG alone respectively and there was no chemical interaction between drug and polymers in the XLBG formulation as confirmed by FTIR studies. The first-pass effect of PPHCL can be avoided by using this formulation. Conclusion: The XLBG matrices offer more precise results than X and LBG matrices due to the effect of a synergistic interaction between the two biopolymers and the lower average size allowing uniform tablet hydration in dissolution media.
M. P. Venkataraju,
D. V. Gowda,
K. S. Rajesh etc
.Xanthan and locust bean gum (from Ceratonia siliqua) matrix tablets for oral controlled delivery of propranolol hydrochloride[J] AJPS, 2007,V2(6): 239-248
2007, Vol. 2 