Abstract Buccal drug delivery has several advantages as an intra-oral route of drug delivery. Being convenient, it provides accessibility to allow for the precise localization of the dosage form. It also offers the opportunity to directly modify tissue permeability, inhibit protease activity and avoid first pass metabolism. A buccoadhesive flexible film was developed for a model drug such as ketoprofen which was incorporated in a suitable polymer matrix with a backing membrane for uni-directional release. The film was evaluated in vitro and in vivo to assess its suitability as a drug delivery system for insoluble drugs with the objective of increasing bioavailability and decreasing the side effects. In the present study suitable formulations for administration of drugs into the oral cavity have been developed using several film-forming and mucoadhesive polymers such as sodium alginate, polycarbophil and carbomer. Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), was selected as the model drug for the study. The prepared films were evaluated for their possible drug-excipient and excipient-excipient interactions by differential scanning calorimetry (DSC). The ?lms were evaluated for their weight, thickness, surface pH, folding endurance, tensile strength, mucoadhesion time, mucoadhesive force, surface characteristics, in vitro, ex vivo and in vivo release. Mucoadhesive force was found to increase with increase in polymer concentration. In vitro drug release for the formulated films was between 47%-93% over a period of 120-360 min. The optimized batch showed good ex vivo release with satisfactory in vitro- in vivo correlation. Buccoadhesive films of ketoprofen can serve as a potential alternative dosage form for drugs having poor bioavailability in the gastrointestinal tract.
Corresponding Authors: Rita Lala, Department of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Plot No 23, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai 400005, India.
Tel: + 91-98-92155738; Fax: + 91-22-22165282
Email: r_r_lala@yahoo.co.in
Cite this article:
Rita Lala,
A. A. Thorat,
C. S. Gargote etc
.Preparation of buccoadhesive polymeric film of ketoprofen and its evaluation[J] AJPS, 2011,V6(6): 267-274
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